Aloe-emodin derived azoles as a new structural type of potential antibacterial agents: design, synthesis, and evaluation of the action on membrane, DNA, and MRSA DNA isomerase
Xinyuan Liang, Narsaiah Battini, Yan‐Fei Sui, Mohammad Fawad Ansari, Linling Gan, Cheng‐He Zhou
Abstract
Tetrazole aloe-emodin<bold>4b</bold>displayed potent efficacy against MRSA, and it was found to rapidly permeate the bacterial membrane to intercalate into DNA and form supermolecule with MRSA DNA isomerase (PDB code: 2XCS).
Topics & Concepts
DNAChemistryAloe emodinCombinatorial chemistryBiochemistryEmodinPhytochemistry and biological activity of medicinal plantsDNA and Nucleic Acid ChemistryBioactive Compounds and Antitumor Agents