CRISPR/Cas9-mediated CysLT1R deletion reverses synaptic failure, amyloidosis and cognitive impairment in APP/PS1 mice
Fang Chen, Shunchang Fang, Yifeng Du, Arijit Ghosh, Miranda N. Reed, Yan Long, Vishnu Suppiramaniam, Susu Tang, Hao Hong
Abstract
R deficiency can mediate several beneficial effects against AD pathogenesis, and genetic/pharmacological ablation of this protein could be a potential therapeutic option for AD.
Topics & Concepts
CRISPRNeuroinflammationSynaptic plasticityNeuroscienceGene knockdownKnockout mouseBiologyAmyloid precursor proteinGene knockoutCell biologyAlzheimer's diseaseMedicineImmunologyReceptorGeneGeneticsDiseaseInflammationInternal medicineAlzheimer's disease research and treatmentsTryptophan and brain disordersNeuroinflammation and Neurodegeneration Mechanisms