GSH-depleting metal–polyphenol-network nanoparticles with dual enzyme activities induce enhanced ferroptosis
Wenxin Zhang, You Li, Di Ke, Yiru Gao, Teng Fei, Guoqing Wang, Yang Shu, Jianhua Wang
Abstract
to generate toxic hydroxyl radicals (˙OH), which may further induce tumor cell death through ferroptosis. In addition, the phosphatase-like activity of Ce-aMOFs may sustainably dephosphorylate NADPH and effectively inhibit intracellular biosynthesis of GSH. Therefore, MEFs ensure down-regulation of intracellular GSH levels and up-regulation of oxidative pressure, which enhance the ferroptosis effect.
Topics & Concepts
ChemistryGlutathioneReactive oxygen speciesGPX4SuperoxideIntracellularHydrogen peroxideBiochemistrySuperoxide dismutasePhosphataseProgrammed cell deathAntioxidantCell biologyEnzymeApoptosisGlutathione peroxidaseBiologyNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisFerroptosis and cancer prognosis