Lysosomal recycling of amino acids affects ER quality control
Ryo Higuchi‐Sanabria, Koning Shen, Naame Kelet, Phillip A. Frankino, Jenni Durieux, Raz Bar‐Ziv, Cierra N. Sing, Enrique J. Garcia, Stefan Homentcovschi, Melissa Sanchez, Rui Wu, Sarah U. Tronnes, Larry Joe, Brant M. Webster, Alex Ahilon-Jeronimo, Samira Monshietehadi, Sofia Dallarda, Corinne L. Pender, Liza A. Pon, Roberto Zoncu, Andrew Dillin
Abstract
mutants. These data implicate a crucial role in recycling lysine, arginine, and glycine in communication between the lysosome and ER.
Topics & Concepts
Amino acidQuality (philosophy)Control (management)ChemistryCell biologyBiologyBiochemistryComputer scienceArtificial intelligencePhysicsQuantum mechanicsAutophagy in Disease and TherapyEndoplasmic Reticulum Stress and DiseaseCalcium signaling and nucleotide metabolism