A self-assembling nanoparticle vaccine targeting the conserved epitope of influenza virus hemagglutinin stem elicits a cross-protective immune response
Yongbo Qiao, Shuang Li, Shenghui Jin, Yi Pan, Yuhua Shi, Wei Kong, Yaming Shan
Abstract
the subcutaneous route, CDh-f and (A + CD)h-f induced robust humoral and cellular immune responses. Furthermore, CDh-f and (A + CD)h-f conferred complete protection against a lethal challenge of H3N2 virus, while no remarkable immune responses and protective effects were detected in the Ah-f group. These results indicate that the CDh-based nanovaccine represents a promising vaccine platform against influenza, and the epitope-conjugated ferritin NPs may be a potential vaccine platform against other infectious viruses, such as SARS-COV-2.
Topics & Concepts
ImmunogenicityHemagglutinin (influenza)Immune systemVirologyEpitopeVirusBiologyInfluenza vaccineInfluenza A virusAntibodyImmunologyInfluenza Virus Research StudiesImmunotherapy and Immune ResponsesSARS-CoV-2 and COVID-19 Research