Breakthroughs in microbiology made possible with organoids
Carlos J. Ramírez‐Flores, Laura J. Knoll
Abstract
To study the host-pathogen interactions with medical and veterinary relevance, researchers have recently applied organoid technology. Organoids revolutionized biomedical research in the last decade due to their ability to recapitulate the physiological properties of whole organs in cell culture. For the field of microbiology, organoids have allowed the study of previously recalcitrant pathogens that would only replicate in their natural host. Nowadays, a large list of viruses, bacteria, fungi, and parasites have been studied using organoids. Here, we describe breakthrough studies that have had or are predicted to have major impacts in the microbiology field, which would not have been possible without the use of organoid technology.