The antioxidative effects of empagliflozin on high glucose‑induced epithelial-mesenchymal transition in peritoneal mesothelial cells via the Nrf2/HO-1 signaling
Ping Shi, Zhoubing Zhan, Xiaojie Ye, Ying Lu, Kai Song, Feng Sheng, Huaying Shen, Peiran Yin
Abstract
experiments, the EMT of HPMCs was induced with 60 mM glucose for 24 h and inhibited by empagliflozin. Empagliflozin suppressed oxidative stress and promoted the protein expression of N-Nrf2 and HO-1 in HG‑stimulated HPMCs, which was reversed by the Nrf2 inhibitor. In conclusion, empagliflozin exerted a protective effect against HG-induced EMT and suppressed oxidative stress in PMCs by activating the Nrf2/HO-1 signaling pathway.
Topics & Concepts
Oxidative stressEmpagliflozinEpithelial–mesenchymal transitionMedicinePharmacologyEndocrinologyChemistryInternal medicineDiabetes mellitusType 2 Diabetes MellitusMetastasisCancerDialysis and Renal Disease ManagementPancreatitis Pathology and TreatmentParathyroid Disorders and Treatments