An in silico study of the effects of cardiovascular aging on carotid flow waveforms and indexes in a virtual population
Irene Suriani, R. Arthur Bouwman, Massimo Mischi, Kevin D. Lau
Abstract
An age-specific virtual population was generated based on a 1-D model of the arterial circulation, including newly defined literature-based specific age variations in carotid vessel properties. Simulated carotid flow/velocity waveforms, indexes, and age trends were statistically validated against in vivo data from the literature. A comprehensive study of the impact of aging on carotid flow waveform morphology was performed, and the mechanisms influencing different carotid indexes were elucidated. Notably, flow augmentation index (FAI) was found to be a strong indicator of local carotid stiffness.
Topics & Concepts
Arterial stiffnessCardiologyMedicineInternal medicineAgeingHemodynamicsPopulationBlood pressureEnvironmental healthCardiovascular Health and Disease PreventionCerebrovascular and Carotid Artery DiseasesBlood Pressure and Hypertension Studies