Test Accuracy of Human Papillomavirus in Urine for Detection of Cervical Intraepithelial Neoplasia
Eliane Rohner, Lisa Rahangdale, Busola Sanusi, Andrea K. Knittel, Laurence M. Vaughan, Kirsty L. Chesko, Brian Faherty, Samantha E. Tulenko, John W. Schmitt, LaHoma Smith Romocki, Vijay Sivaraman, Julie A. Nelson, Jennifer S. Smith
Abstract
cutoff value of ≤40, 90% sensitivity was achieved for urine-based hrHPV testing. Agreement between results for urine samples and self-collected cervicovaginal samples (kappa = 0.58) or provider-collected cervical samples (kappa = 0.54) was moderate. Urine-based hrHPV testing may be a promising approach to improve cervical cancer screening coverage, especially among women with limited access to health care.
Topics & Concepts
ColposcopyCervical intraepithelial neoplasiaHuman papillomavirusMedicineUrineGynecologyCervical screeningPapillomaviridaeObstetricsIntraepithelial neoplasiaCervical cancerCervixInternal medicineCancerProstateCervical Cancer and HPV ResearchReproductive tract infections researchGenital Health and Disease