The Role of Long Noncoding RNA BST2-2 in the Innate Immune Response to Viral Infection
Shengwen Chen, Xiang Huang, Qinya Xie, Qian Liu, Haizhen Zhu
Abstract
Innate immunity is an important part of the human immune system to resist the invasion of foreign pathogens. IRF3 plays a critical role in the innate immune response to viral infection. In this study, we demonstrated that lncBST2-2 plays an important role in innate immunity. Virus-induced lncBST2-2 positively regulates innate immunity by interacting with IRF3 and blocking the dephosphorylation effect of RACK1-PP2A complex on IRF3, thus inhibiting viral infection. Our study provides a new insight into the role of lncBST2-2 in the regulation of IRF3 signaling activation.
Topics & Concepts
BiologyInnate immune systemRNAImmune systemViral infectionLong non-coding RNAVirologyInnate lymphoid cellImmunologyGeneticsVirusGeneCancer-related molecular mechanisms researchinterferon and immune responsesViral Infections and Vectors