Liposomal formulations of anticancer copper(<scp>ii</scp>) thiosemicarbazone complexes
Marlene Mathuber, Sonja Hager, Bernhard K. Keppler, Petra Heffeter, Christian R. Kowol
Abstract
distinctly higher copper plasma levels and a continuous release could be observed for the liposomal formulation compared to free Cu-triapine. Taken together, the here presented nanoformulation of Cu-triapine is an important step further to increase the plasma half-life time and tumor targeting properties of anticancer thiosemicarbazones.
Topics & Concepts
LiposomeChemistryCopperDrugSemicarbazonePharmacologyCombinatorial chemistryStereochemistryBiochemistryMedicineOrganic chemistryMetal complexes synthesis and propertiesNanoparticle-Based Drug DeliveryNanocluster Synthesis and Applications