Neuron-glia crosstalk and inflammatory mediators in migraine pathophysiology
Yine Song, Shaoru Zhao, Peiyue Peng, Chengcheng Zhang, Yuhan Liu, Ying Chen, Yuxi Luo, Bin Li, Lu Liu
Abstract
PBR28-targeted imaging for visualizing astrocyte activation and single-cell sequencing for exploring cellular heterogeneity, represent breakthroughs in understanding the mechanisms of neuroinflammation in migraine. By considering factors for personalized treatments, estrogen and TRPM8 emerge as promising therapeutic targets regarding sexual dimorphism. These advancements may help bridge the gap between preclinical findings and clinical applications, ultimately leading to more precise and personalized options for migraine patients.
Topics & Concepts
PathophysiologyNeuroscienceCrosstalkMigraineNeuronMedicinePsychologyPathologyInternal medicinePhysicsOpticsMigraine and Headache StudiesNeurological Disorders and TreatmentsBiochemical effects in animals