Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca <sup>2+</sup> signaling during T cell activation
Feng Gu, Aileen Krüger, Hannes Roggenkamp, Rick Alpers, Dmitri Lodygin, Vincent Jaquet, Franziska Möckl, Lola C. Hernandez, Kai J Winterberg, Andreas Bauche, Anette Rosche, Helmut Grasberger, John Y. Kao, Daniel Schetelig, René Werner, Katrin Schröder, Michael Carty, Andrew Bowie, Samuel Huber, Chris Meier, Hans‐Willi Mittrücker, Jöerg Heeren, Karl‐Heinz Krause, Alexander Flügel, Björn‐Philipp Diercks, Andreas H. Guse
Abstract
signaling between 4 and 12 min after stimulation. Our findings suggest that a DUOX2- and G6PD-catalyzed redox cycle rapidly produces and degrades NAADP through NAADPH as an inactive intermediate.
Topics & Concepts
EnzymeCell biologySignal transductionChemistryCell signalingNADPH oxidaseBiochemistryBiologyCalcium signaling and nucleotide metabolismAdenosine and Purinergic Signaling