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Engineered trimeric ACE2 binds viral spike protein and locks it in “Three-up” conformation to potently inhibit SARS-CoV-2 infection

Liang Guo, Wenwen Bi, Xinling Wang, Wei Xu, Renhong Yan, Yuanyuan Zhang, Kai Zhao, Yaning Li, Mingfeng Zhang, Xia Cai, Shibo Jiang, Youhua Xie, Qiang Zhou, Lu Lu, Bobo Dang

2020Cell Research104 citationsDOIOpen Access PDF

Topics & Concepts

BiologySpike ProteinVirologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakProtein structureBiochemistryInfectious disease (medical specialty)OutbreakMedicineDiseasePathologySARS-CoV-2 and COVID-19 ResearchViral Infections and Immunology Researchinterferon and immune responses
Engineered trimeric ACE2 binds viral spike protein and locks it in “Three-up” conformation to potently inhibit SARS-CoV-2 infection | Litcius