Exploration of novel cationic amino acid-enriched short peptides: design, SPPS, biological evaluation and <i>in silico</i> study
Prashant K. Chandole, Tushar Janardan Pawar, José Luís Olivares-Romero, Sunil Tivari, Bianney Garcia Lara, Harun Patel, Iqrar Ahmad, Enrique Delgado‐Alvarado, Siddhant V. Kokate, Yashwantsinh Jadeja
Abstract
. Utilizing molecular docking techniques, we delved into the molecular interactions underpinning the peptides' action against these microorganisms. The results revealed a spectrum of inhibitory activities, with certain peptide sequences displaying pronounced effectiveness across various pathogens. These findings underscore the peptides' potential as promising antimicrobial agents, with molecular docking offering valuable insights into their mechanisms of action. This study enriches antimicrobial peptide (AMP) research by identifying promising candidates for further refinement and development toward therapeutic application, highlighting their significance in addressing the urgent issue of AMR.