Liver Histotripsy Mediated Abscopal Effect—Case Report
Joan Vidal-Jové, Xavier Serres, Timothy J. Ziemlewicz, Jonathan M. Cannata
Abstract
We present a case report that shows an abscopal effect in the context of a safety and efficacy clinical trial for histotripsy as ablation technique in liver tumors. The abscopal effect appears in the form of reduction in the volume of nontreated tumor lesions in the same organ, as well as sustained reduction of tumor marker [carcinoembryonic antigen (CEA)] that extends weeks away of the procedure. Histotripsy is a novel noninvasive, nonthermal, and nonionizing precise ablation technique for tissue destruction guided by ultrasonography. We discuss the feasibility of this technique compared with other focal therapies and its possibilities as immune system enhancer.
Topics & Concepts
Abscopal effectCarcinoembryonic antigenMedicineAblationUltrasonographyContext (archaeology)Immune systemRadiologyCancer researchBiomedical engineeringImmunotherapyInternal medicineBiologyImmunologyCancerPaleontologyHepatocellular Carcinoma Treatment and PrognosisLiver physiology and pathologyPancreatic and Hepatic Oncology Research