Discovery of novel and potent PARP/PI3K dual inhibitors for the treatment of cancer
Zhengyang Wu, Ying Bai, Jiaming Jin, Teng Jiang, Hui Shen, Qiurong Ju, Qihua Zhu, Yungen Xu
Topics & Concepts
Poly ADP ribose polymerasePI3K/AKT/mTOR pathwayChemistryPARP inhibitorCardiotoxicityIn vivoCancerIC50PharmacologyCancer researchIn vitroPolymeraseBiochemistryMedicineInternal medicineSignal transductionBiologyEnzymeToxicityGeneticsOrganic chemistryPARP inhibition in cancer therapyDNA Repair MechanismsCRISPR and Genetic Engineering