Loss-of-function mutations in the melanocortin 4 receptor in a UK birth cohort
Kaitlin H. Wade, Brian Lam, Audrey Melvin, Warren W. Pan, Laura J. Corbin, David A. Hughes, Kara Rainbow, Jianhua Chen, Katie Duckett, Xiaoming Liu, Jacek Mokrosiński, Alexander Mörseburg, S Neaves, Alice Williamson, Chen Zhang, I. Sadaf Farooqi, Giles S.H. Yeo, Nicholas J. Timpson, Stephen O’Rahilly
Topics & Concepts
Melanocortin 4 receptorCohortAnthropometryBody mass indexObesityInternal medicineEndocrinologyBiologyLongitudinal studyNonsynonymous substitutionGeneticsLoss functionMedicinePhenotypeMelanocortinGeneReceptorPathologyGenomeRegulation of Appetite and ObesityObesity, Physical Activity, DietGenetic Associations and Epidemiology