Iron porphyrin catalysed light driven C–H bond amination and alkene aziridination with organic azides
Yi-Dan Du, Cong‐Ying Zhou, Wai‐Pong To, Hai‐Xu Wang, Chi‐Ming Che
Abstract
C-H amination and alkene aziridination with selectivity by using organic azides as the nitrogen source under blue LED light (469 nm) irradiation. The photochemical reactions display chemo- and regio-selectivity and are effective for the late-stage functionalization of natural and bioactive compounds with complexity. Mechanistic studies revealed that iron porphyrin plays a dual role as a photosensitizer and as a catalyst giving rise to a reactive iron-nitrene intermediate for subsequent C-N bond formation.
Topics & Concepts
AminationPorphyrinAlkeneChemistrySubstrate (aquarium)SelectivityPhotochemistryOrganic chemistryCatalysisCombinatorial chemistryMedicinal chemistryOceanographyGeologySynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques