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Hexachlorophene, a selective SHP2 inhibitor, suppresses proliferation and metastasis of KRAS-mutant NSCLC cells by inhibiting RAS/MEK/ERK and PI3K/AKT signaling pathways

Naijie Fu, Ruiying Xi, Xiaoke Shi, Runze Li, Zhonghui Zhang, Lingyu Li, Guolin Zhang, Fei Wang

2022Toxicology and Applied Pharmacology23 citationsDOI

Topics & Concepts

KRASPI3K/AKT/mTOR pathwayProtein kinase BCancer researchMAPK/ERK pathwayBiologyCell growthChemistryProto-oncogene tyrosine-protein kinase SrcPhosphorylationSignal transductionCell biologyCancerBiochemistryColorectal cancerGeneticsProtein Tyrosine PhosphatasesCytokine Signaling Pathways and InteractionsGalectins and Cancer Biology
Hexachlorophene, a selective SHP2 inhibitor, suppresses proliferation and metastasis of KRAS-mutant NSCLC cells by inhibiting RAS/MEK/ERK and PI3K/AKT signaling pathways | Litcius