Rational drug design of CB2 receptor ligands: from 2012 to 2021
Yan-Ran Wu, Jia-qin Tang, Wannian Zhang, Chunlin Zhuang, Ying Shi
Abstract
During these processes, the balance between selectivity, activity, and pharmacokinetic properties needs to be achieved. Hence, we summarized some reported ligands on the basis of the optimization strategies in recent 10 years, and the limitations and future directions.
Topics & Concepts
Cannabinoid receptor type 2Cannabinoid receptorCannabinoidReceptorChemistryPharmacologyDrugBiochemistryBiologyAgonistCannabis and Cannabinoid ResearchPharmacological Receptor Mechanisms and EffectsNeurotransmitter Receptor Influence on Behavior