Molecular Mechanisms of Resistance to Ceftazidime/Avibactam in Clinical Isolates of <i>Enterobacterales</i> and Pseudomonas aeruginosa in Latin American Hospitals
María F. Mojica, Elsa De La Cadena, Juan Carlos García-Betancur, Jessica Porras, Isabella Novoa-Caicedo, Laura Páez-Zamora, Christian Pallares, Tobías Manuel Appel, Marcela Rádice, Paulo Castañeda-Méndez, Ana Cristina Gales, José M. Munita, María Virginia Villegas
Abstract
In this manuscript, we determine the molecular mechanisms of ceftazidime-avibactam resistance in Enterobacterales and P. aeruginosa isolates from five Latin American countries. Our results reveal a low rate of resistance to ceftazidime-avibactam among Enterobacterales ; in contrast, resistance in P. aeruginosa has proven to be more complex, as it might involve multiple known and possibly unknown resistance mechanisms.
Topics & Concepts
Ceftazidime/avibactamPseudomonas aeruginosaCeftazidimeMedicineLatin AmericansIntensive care medicineMicrobiologyBiologyGeneticsBacteriaPolitical scienceLawAntibiotic Resistance in BacteriaAntibiotic Use and ResistanceAntibiotics Pharmacokinetics and Efficacy