Cascade dearomative [4 + 2] cycloaddition of indoles with <i>in situ</i> generated <i>ortho</i>-quinone methides: practical access to divergent indoline-fused polycycles
Pei-Zhen Dong, Bin Qiu, Xiao‐De An, Jian Xiao
Abstract
A rationally designed cascade dearomative [4 + 2] cycloaddition of indoles with in situ generated o -QM has been developed to assemble indoline-fused polycycles divergently with high yields and excellent diastereoselectivity in one step.
Topics & Concepts
IndolineCycloadditionCascadeIn situChemistryQuinoneCombinatorial chemistryStereochemistryOrganic chemistryCatalysisChromatographySynthesis of Indole DerivativesAxial and Atropisomeric Chirality SynthesisCatalytic C–H Functionalization Methods