Noninvasive near-infrared light triggers the remote activation of thermo-responsive TRPV1 channels in neurons based on biodegradable/photothermal polymer micelles
Wei-Hsu Chen, Taiki Onoe, Masao Kamimura
Abstract
We developed a novel biodegradable/photothermal polymer micelle-based remote-activation method for a temperature-sensitive TRPV1 ion channel. The developed polymer micelles can serve as a novel noninvasive remote-activation tool for neuronal cells.
Topics & Concepts
Photothermal therapyMicellePolymerMaterials scienceInfraredNanotechnologyPhotothermal effectChemistryOpticsComposite materialOrganic chemistryAqueous solutionPhysicsPhotoreceptor and optogenetics researchCircadian rhythm and melatoninBiochemical effects in animals