pH-Controlled Intramolecular Decarboxylative Cyclization of Biarylacetic Acids: Implication on Umpolung Reactivity of Aroyl Radicals
Joydev K. Laha, Upma Gulati, Saima Saima, Tim Schulte, Martin Breugst
Abstract
A simple approach for the intramolecular aroylation of electron-rich arenes under mild conditions has been developed. A pH-controlled polarity umpolung strategy can be used to synthesize different fluorenones, which are important building blocks for biological applications. Unlike previous acylation reactions involving nucleophilic aroyl radicals, this approach likely relies on in situ generated electrophilic aroyl radicals. Detailed mechanistic and computational investigations provide detailed insights into the reaction mechanism and support the hypothesis of a pH-mediated umpolung.
Topics & Concepts
UmpolungChemistryNucleophileIntramolecular forceReactivity (psychology)RadicalElectrophileAcylationCombinatorial chemistryComputational chemistryOrganic chemistryCatalysisPathologyAlternative medicineMedicineRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques