A taRNA vaccine candidate induces a specific immune response that protects mice against Chikungunya virus infections
Christin Schmidt, Erik Haefner, Julia Gerbeth, Tim Beißert, Uğur Şahin, Mario Perković, Barbara S. Schnierle
Abstract
in a mouse model. Notably, mice were protected against a high-dose CHIKV challenge infection with two vaccine doses of only 1.5 μg RNA. Therefore, taRNAs are a promising safe and efficient vaccination strategy against CHIKV infections.
Topics & Concepts
ChikungunyaVirologyImmune systemVirusAlphavirusBiologyImmunologyMedicineMosquito-borne diseases and controlViral Infections and VectorsVirology and Viral Diseases