Enantioselective Nickel-Catalyzed Hydrocyanative Desymmetrization of Norbornene Derivatives
Feilong Sun, Ting Wang, Gui‐Juan Cheng, Xianjie Fang
Abstract
A nickel-catalyzed enantioselective hydrocyanation of N-aryl 5-norbornene-endocis-2,3-dicarboximides was reported. This desymmetrization process allows for a quick construction of both continuous stereogenic carbon centers and remote N–CAr atropisomeric chirality. Mechanism studies indicated that the resident carbonyl group of the substrates plays a key role in the enantioselectivity.
Topics & Concepts
DesymmetrizationEnantioselective synthesisNorborneneHydrocyanationStereocenterNickelCatalysisChemistryArylChirality (physics)StereochemistryOrganic chemistryMonomerQuarkQuantum mechanicsPolymerChiral symmetry breakingNambu–Jona-Lasinio modelPhysicsAlkylAxial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chiralityAsymmetric Synthesis and Catalysis