Cardiac tissue remodeling in healthy aging: the road to pathology
Evan Tracy, Gabrielle Rowe, Amanda J. LeBlanc
Abstract
This review aims to highlight the normal physiological remodeling that occurs in healthy aging hearts, including changes that occur in contractility, conduction, valve function, large and small coronary vessels, and the extracellular matrix. These "normal" age-related changes serve as the foundation that supports decreased plasticity and limited ability for tissue remodeling during pathophysiological states such as myocardial ischemia and heart failure. This review will identify populations at greater risk for poor tissue remodeling in advanced age along with present and future therapeutic strategies that may ameliorate dysfunctional tissue remodeling in aging hearts.
Topics & Concepts
ContractilityExtracellular matrixMedicineVentricular remodelingPathophysiologyHeart failureCardiologyPathologicalInternal medicineFibrosisPathologyBiologyCell biologyTissue Engineering and Regenerative MedicineCardiac Fibrosis and RemodelingElectrospun Nanofibers in Biomedical Applications