Comparison of the effect of cigarette smoke on mesenchymal stem cells and dental stem cells
Brandon Nguyen, Tamer Alpagot, Heesoo Oh, David M. Ojcius, Nan Xiao
Abstract
The persistent prevalence of cigarette smoking continues to contribute to preventable disease and death in the United States. Although much is known about the deleterious systemic effects of cigarette smoke and nicotine, some clinically relevant areas, such as the impact of cigarette smoke and nicotine on stem cells and the subsequent implications in regenerative medicine, still remain unclear. This review focuses on recent studies on the effect of cigarette smoke and one of its deleterious components, nicotine, on mesenchymal stem cells, with an emphasis on dental stem cells.
Topics & Concepts
Cigarette smokeMesenchymal stem cellStem cellNicotineMedicineSmokeRegenerative medicineCigarette smokingPhysiologyEnvironmental healthPathologyBiologyInternal medicineCell biologyChemistryOrganic chemistryMesenchymal stem cell research