The distinct roles of zinc finger CCHC-type (ZCCHC) superfamily proteins in the regulation of RNA metabolism
Yishu Wang, Yu Yu, Yidan Pang, Haojun Yu, Wenqi Zhang, Xian Zhao, Jianxiu Yu
Abstract
-C, are accepted to have high-affinity binding to single-stranded nucleic acids, especially single-stranded RNAs. In human beings 25 ZCCHC proteins have been annotated in the HGNC database. Of interest is that among the family, most members are involved in the multiple steps of RNA metabolism. In this review, we focus on the diverged roles of human ZCCHC proteins on RNA transcription, biogenesis, splicing, as well as translation and degradation.
Topics & Concepts
Zinc fingerBiologyRNA-binding proteinRNA splicingBiogenesisRNAAlternative splicingGeneticsRING finger domainTranscription (linguistics)Translation (biology)LIM domainTranscription factorCell biologyComputational biologyGene isoformGeneMessenger RNAPhilosophyLinguisticsRNA Research and SplicingRNA modifications and cancerRNA and protein synthesis mechanisms