Insights gained from computational modeling of YAP/TAZ signaling for cellular mechanotransduction
Hamidreza Jafarinia, Ali Khalilimeybodi, Jorge Barrasa‐Fano, Stephanie I. Fraley, Padmini Rangamani, Aurélie Carlier
Abstract
YAP/TAZ signaling pathway is regulated by a multiplicity of feedback loops, crosstalk with other pathways, and both mechanical and biochemical stimuli. Computational modeling serves as a powerful tool to unravel how these different factors can regulate YAP/TAZ, emphasizing biophysical modeling as an indispensable tool for deciphering mechanotransduction and its regulation of cell fate. We provide a critical review of the current state-of-the-art of computational models focused on YAP/TAZ signaling.
Topics & Concepts
CrosstalkMechanotransductionComputational modelSignal transductionCell biologyNeuroscienceComputer scienceBiologyEngineeringElectronic engineeringSimulationHippo pathway signaling and YAP/TAZCellular Mechanics and InteractionsPlant Surface Properties and Treatments