Albumin-Mediated Uptake Improves Human Clearance Prediction for Hepatic Uptake Transporter Substrates Aiding a Mechanistic In Vitro-In Vivo Extrapolation (IVIVE) Strategy in Discovery Research
Na Li, Akshay Badrinarayanan, Kazuya Ishida, Xingwen Li, John G. Roberts, Shuai Wang, Mike Hayashi, Anshul Gupta
Topics & Concepts
In vivoChemistryIn vitroHepatocyteHuman serum albuminPharmacologyExtrapolationAlbuminTransporterBiochemistryBiologyMathematicsGeneMathematical analysisBiotechnologyDrug Transport and Resistance MechanismsPharmacogenetics and Drug MetabolismProtein Interaction Studies and Fluorescence Analysis