The Role of Non-Coding RNAs in Liver Disease, Injury, and Regeneration
Melissa M. Rowe, Klaus H. Kaestner
Abstract
Non-coding RNAs (ncRNAs) have diverse functions in health and pathology in many tissues, including the liver. This review highlights important microRNAs (miRs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) in liver disease and regeneration. Greater attention is given to more prevalent and well characterized RNAs, including: miR-122, miR-21, the let-7 family of miRs, miR-451a, miR-144, and MALAT1.
Topics & Concepts
microRNAMALAT1Long non-coding RNABiologyNon-coding RNACircular RNASmall nucleolar RNAComputational biologyRegeneration (biology)RNADiseaseBioinformaticsGeneticsGeneMedicinePathologyCircular RNAs in diseasesMicroRNA in disease regulationCancer-related molecular mechanisms research