Restraint of Fumarate Accrual by HIF-1α Preserves miR-27a-Mediated Limitation of Interleukin 10 during Infection of Macrophages by Histoplasma capsulatum
Heather M. Evans, Destiny F. Schultz, Adam J. Boiman, Melanie C. McKell, Joseph E. Qualls, George S. Deepe
Abstract
-infected macrophages. The absence of HIF-1α results in excessive fumarate production that alters miRNA-27a regulation of interleukin-10. HIF-1α thus preserves the capacity of macrophages to transition from a permissive intracellular niche to the site of pathogen killing.
Topics & Concepts
Intracellular parasiteProinflammatory cytokineMicrobiologyMacrophageBiologyHistoplasmaIntracellularHistoplasmosisCytokineImmunologyInterleukin 10Immune systemInterleukinPathogenPhagocyteCoinfectionHistoplasma capsulatumSalmonella entericaChemokineCryptococcosisMononuclear phagocyte systemInflammationFungal Infections and StudiesToxoplasma gondii Research StudiesNail Diseases and Treatments