Downregulated METTL14 accumulates BPTF that reinforces super-enhancers and distal lung metastasis via glycolytic reprogramming in renal cell carcinoma
Chuanjie Zhang, Li Chen, Yihan Liu, Jingyi Huang, Ao Liu, Yang Xu, Yan Shen, Hongchao He, Danfeng Xu
Abstract
A modification and the METTL14/BPTF axis in the epigenetic and metabolic remodeling of mRCC, highlighting AU1 as a vital therapeutic candidate.
Topics & Concepts
Cancer researchBiologyCarcinogenesisChromatinMetastasisChromatin remodelingEnhancerReprogrammingCell biologyTranscription factorCancerCellGeneBiochemistryGeneticsRNA modifications and cancerCancer-related gene regulationProtein Degradation and Inhibitors