Comprehensive Comparison of Seven SARS-CoV-2-Specific Surrogate Virus Neutralization and Anti-Spike IgG Antibody Assays Using a Live-Virus Neutralization Assay as a Reference
Marianne Graninger, Claudia Jani, Elisabeth Reuberger, Katja Prüger, Philipp Gaspar, David Niklas Springer, Christian Borsodi, Lisa Weidner, Susanne Rabady, Elisabeth Puchhammer‐Stöckl, Christof Jungbauer, Eva Höltl, Judith H. Aberle, Karin Stiasny, Lukas Weseslindtner
Abstract
While the measurement of neutralizing antibodies is considered a valuable tool in assessing protection against SARS-CoV-2, neutralization tests employ live-virus isolates and cell culture, requiring advanced laboratory biosafety levels. Including a large sample panel (over 700 samples), this study provides adapted cutoff values calculated for seven commercial immunoassays (including four surrogate neutralization assays and a protein-based microarray) that robustly correlate with specific titers of neutralizing antibodies.