A low molecular weight brown algae <i>Laminaria japonica</i> glycan modulation of gut microbiota and body weight in mice
Zhen Jin, Zhifeng Fang, Zhangming Pei, Hongchao Wang, Jinlin Zhu, Yuan Kun Lee, Hao Zhang, Jianxin Zhao, Wenwei Lu, Wei Chen
Abstract
to regulate gut amino acid metabolism and glycometabolism. Moreover, LJNP showed a weight loss effect and better protection of the intestinal barrier than 2'FL. We further employed LJNP and 2'FL on a germ-free mice model. Interestingly, the body weight management was not microbiome mediated. This study showed that LJNP can ameliorate the intestinal barrier through modulation of the gut microbiota, maintain the blood glucose level, and regulate body weight and the antioxidant function. Although the benefits of LJNP on host health were partly revealed, mechanisms such as the weight loss effect require further study.
Topics & Concepts
Brown algaeGlycanGut floraAlgaeBiologyFucoidanPrebioticLaminariaBrown seaweedBotanyFood scienceBiochemistryPolysaccharideGlycoproteinSeaweed-derived Bioactive CompoundsGut microbiota and healthMicrobial Metabolites in Food Biotechnology