Lentiviral delivery of co-packaged Cas9 mRNA and a Vegfa-targeting guide RNA prevents wet age-related macular degeneration in mice
Sikai Ling, Shiqi Yang, Xinde Hu, Di Yin, Yao Dai, Xiaoqing Qian, Dawei Wang, Xiaoyong Pan, Jiaxu Hong, Xiaodong Sun, Hui Yang, Søren R. Paludan, Yujia Cai
Topics & Concepts
Macular degenerationMessenger RNARNAVascular endothelial growth factor ADegeneration (medical)MedicineCell biologyMolecular biologyVEGF receptorsBiologyCancer researchOphthalmologyVascular endothelial growth factorGeneticsGeneCRISPR and Genetic EngineeringRetinal Development and DisordersRNA regulation and disease