Multidrug-Resistant Bacterial Infections in U.S. Hospitalized Patients, 2012–2017
John A. Jernigan, Kelly M Hatfield, Hannah Wolford, Richard E. Nelson, Babatunde Olubajo, Sujan Reddy, Natalie McCarthy, Prabasaj Paul, L. Clifford McDonald, Alex Kallen, Anthony E. Fiore, Michael Craig, James Baggs
Abstract
BACKGROUND: Multidrug-resistant (MDR) bacteria that are commonly associated with health care cause a substantial health burden. Updated national estimates for this group of pathogens are needed to inform public health action. METHODS: . RESULTS: infection (from 13.10 to 9.43 per 10,000), with decreases ranging from -20.5% to -39.2%. The incidence of carbapenem-resistant Enterobacteriaceae infection did not change significantly (from 3.36 to 3.79 cases per 10,000 hospitalizations). The incidence of ESBL infection increased by 53.3% (from 37.55 to 57.12 cases per 10,000 hospitalizations), a change driven by an increase in community-onset cases. CONCLUSIONS: Health care-associated antimicrobial resistance places a substantial burden on patients in the United States. Further work is needed to identify improved interventions for both the inpatient and outpatient settings. (Funded by the Centers for Disease Control and Prevention.).