Optimization of pyrazolo[1,5-a]pyrimidines lead to the identification of a highly selective casein kinase 2 inhibitor
Andreas Krämer, Christian Georg Kurz, Benedict‐Tilman Berger, Ibrahim-Ethem Celik, Amelie Tjaden, Francesco Greco, Stefan Knapp, Thomas Hanke
Topics & Concepts
Casein kinase 2KinaseChemistryMoietyThreonineDrug discoveryBiochemistryLead compoundCasein kinase 1SerineProtein kinase AIn vitroStereochemistryPhosphorylationCyclin-dependent kinase 2Protein Kinase Regulation and GTPase SignalingChronic Myeloid Leukemia TreatmentsPI3K/AKT/mTOR signaling in cancer