Predicting Neurodegenerative Disease Using Prepathology Gut Microbiota Composition: a Longitudinal Study in Mice Modeling Alzheimer’s Disease Pathologies
Emily M. Borsom, Kathryn A Conn, Christopher R. Keefe, Chloe Herman, Gabrielle M Orsini, Allyson H. Hirsch, Melanie Palma Avila, George Testo, Sierra A. Jaramillo, Evan Bolyen, Keehoon Lee, J. Gregory Caporaso, Emily K. Cope
Abstract
Recent studies have demonstrated alterations in the gut microbiota composition in mice modeling Alzheimer’s disease (AD) pathologies; however, these studies have only included up to 4 time points. Our study is the first of its kind to characterize the gut microbiota of a transgenic AD mouse model, fortnightly, from 4 weeks of age to 52 weeks of age, to quantify the temporal dynamics in the microbial composition that correlate with the development of disease pathologies and host immune gene expression.
Topics & Concepts
BiologyGut floraPathologyGlial fibrillary acidic proteinImmunologyMedicineImmunohistochemistryGut microbiota and healthTryptophan and brain disordersClostridium difficile and Clostridium perfringens research