A TiO<sub>2</sub>-based bioprobe enabling excellent SERS activity in the detection of diverse circulating tumor cells
Yanping Xu, Jie Lin, Xiaoxia Wu, Xiawei Xu, Dinghu Zhang, Yujiao Xie, Ting Pan, Yiwei He, Aiguo Wu, Guoliang Shao
Abstract
-based SERS bioprobe can be effectively utilized in detecting four diverse types of cancer cells in rabbit blood, which shows good sensitivity of the SERS detection technology. Finally, precise targeting of CTCs based on the SERS bioprobe with the function of fluorescence imaging is also confirmed by the fluorescence colouration test. This work offers a novel strategy for CTC detection and the development of non-noble metal semiconductor-based SERS platforms for tumor diagnosis.
Topics & Concepts
Materials scienceNanotechnologyProcess engineeringEngineeringGold and Silver Nanoparticles Synthesis and ApplicationsAdvanced biosensing and bioanalysis techniquesNanoplatforms for cancer theranostics