Genome integrity and neurogenesis of postnatal hippocampal neural stem/progenitor cells require a unique regulator Filia
Jingzheng Li, Yafang Shang, Lin Wang, Bo Zhao, Chunli Sun, Jiali Li, Siling Liu, Cong Li, Min Tang, Fei‐Long Meng, Ping Zheng
Abstract
mice had impaired hippocampal NSPC proliferation and neurogenesis and were deficient in learning, memory, and mood regulations. Thus, our study provided the first proof of concept demonstrating the region-specific regulations of DSB formation and repair in subtypes of NSPCs.
Topics & Concepts
NeurogenesisHippocampal formationNeural stem cellProgenitor cellBiologyCell biologyDNA repairStem cellNeuroscienceDNAGeneticsNeurogenesis and neuroplasticity mechanismsDNA Repair MechanismsMicrotubule and mitosis dynamics