Poly β-Cyclodextrin/Quaternary Ammoniated Chitosan Cryogel with a Porous Structure for Effective Hemostasis
Min Tan, Fan Liu, Li-Guo Liao, Junfeng Feng, Fu‐Zhong Zhang, Shu-Ting Fan, Jiaxin Wang, Kun Guo, Bang‐Jing Li, Sheng Zhang
Abstract
Uncontrolled bleeding is one of the most important causes threatening human health, but quick hemostasis remains a challenge. We prepared porous cryogels with poly β-cyclodextrin (Pβ-CD) and quaternary ammoniated chitosan (QCs). Pβ-CD acts as a "water-grabbing agent" to assist QCs' ability to absorb and concentrate blood rapidly. The rat-tail amputation model and liver injury model exhibited that cryogels had excellent hemostatic performance. Moreover, cryogels showed good antibacterial activity and biocompatibility. Therefore, these cryogels can be used as potential hemostatic materials.
Topics & Concepts
ChitosanHemostasisBiocompatibilityHemostatic AgentCyclodextrinMaterials scienceAntibacterial activityChemistryChromatographyBacteriaSurgeryBiochemistryMedicineMetallurgyGeneticsBiologyHemostasis and retained surgical itemsTrauma, Hemostasis, Coagulopathy, ResuscitationHemophilia Treatment and Research