Lawsozaheer, a new chromone produced by an endophytic fungus <i>Paecilomyces variotii</i> isolated from <i>Lawsonia Alba</i> Lam. inhibits the growth of <i>Staphylococcus aureus</i>
Zaheer Abbas, Bina S. Siddiqui, Saleem Shahzad, Samia Sattar, Sabira Begum, Anum Batool, M. Iqbal Choudhary
Abstract
One new chromone, lawsozaheer (1), and five known compounds 4-(2-hydroxyethyl) phenol (2), viriditoxin (3), stigmasta-4,6,8(14),22-tetraen-3-one (4), β-sitosterol (5) and stigmasterol (6) were isolated from the fungal broth of Paecilomyces variotii. Their structures were elucidated using spectroscopic data. The configuration of 1 was determined by Horeau’s method. The broth extract and compound 1 showed highly selective activity against Staphylococcus aureus (NCTC 6571) bacterium with 83.19 and 84.26% inhibition respectively at 150 µg/mL, comparing well with that of standard drug ofloxacin (87.013% inhibition at 100 µg/mL). Broth extract also showed 75, and 40% inhibition of Candida albicans and Fusarium lini, respectively.