Biomechanical characterization of a fibrinogen–blood hydrogel for human dental pulp regeneration
Sofia Silvia Piglionico, Béla Varga, Orsolya Páll, Olivier Romieu, Csilla Gergely, Frédéric Cuisinier, Bernard Levallois, Ivan Panayotov
Abstract
fibrinogen and 50% blood of the Fbg solution volume has similar elasticity to human dental pulp and adequate degradation and swelling rates. It also allows cell survival and ECM secretion and enhances endothelial cell migration and formation of neovessel-like structures.
Topics & Concepts
Pulp (tooth)Biomedical engineeringFibrinogenChemistryDental pulp stem cellsDentistryEx vivoRoot canalExtracellular matrixAtomic force microscopyMaterials scienceMedicineNanotechnologyBiochemistryIn vitroEndodontics and Root Canal TreatmentsBlood properties and coagulationDrilling and Well Engineering