Engineered collagen/PLLA composite fillers to induce rapid and long-term collagen regeneration
Shuhua Chang, Miaoran Zhao, Wenxia Gao, Jun Cao, Bin He
Abstract
. Compared to the single collagen and PLLA microspheres, the Col@PLLA composite fillers showed significant collagen regeneration after injecting for 5 days. The regenerated type III and type I collagens of Col@PLLA maintained high levels after 4 months post-implantation. The inflammation response further validated the regenerative mechanism and long-lasting potential of this product. The Col@PLLA fillers achieved a significant enhancement in collagen regeneration.
Topics & Concepts
Regeneration (biology)Materials scienceComposite numberComposite materialTerm (time)Cell biologyQuantum mechanicsPhysicsBiologyPeriodontal Regeneration and TreatmentsElectrospun Nanofibers in Biomedical ApplicationsCollagen: Extraction and Characterization