K<sub>ATP</sub> channels in lymphatic function
Michael J. Davis, Hae Jin Kim, Colin G. Nichols
Abstract
K ATP channels function as negative regulators of active lymphatic pumping and lymph transport. This review summarizes and critiques the evidence for the expression of specific K ATP channel subunits in lymphatic smooth muscle and endothelium, the roles that they play in normal lymphatic function, and their possible involvement in multiple diseases, including metabolic syndrome, lymphedema, and Cantú syndrome. For each of these topics, suggestions are made for directions for future research.
Topics & Concepts
Lymphatic systemLymphedemaFunction (biology)Lymphatic EndotheliumLymphLymphangiogenesisSmooth muscleCell biologyBiologyMedicinePathologyInternal medicineCancerBreast cancerMetastasisLymphatic System and DiseasesHydrogen's biological and therapeutic effectsDietary Effects on Health