KIF15 promotes human glioblastoma progression under the synergistic transactivation of REST and P300
Wendan Yu, Shilong Han, Sheng Hu, Liyuan Ru, Chunyu Hua, Guoqing Xue, Guohui Zhang, Kuan Lv, Hanxiao Ge, Meiyi Wang, Lina Zheng, Jie Zhou, Shuai Hou, Yun Teng, Wuguo Deng, Wei Guo
Abstract
and the combinational treatment of cell cycle inhibitor Palbociclib with P300 HAT inhibitor inhibited GBM xenografts survival more significantly. Our findings indicate that KIF15 promotes GBM progression under the synergistic transactivation of REST and P300. P300/REST/KIF15 signaling axis is expected to be served as a cascade of candidate therapeutic targets in anti-GBM.
Topics & Concepts
TransactivationRest (music)GlioblastomaCancer researchBiologyMedicineInternal medicineGeneticsGeneTranscription factorRNA Research and SplicingCancer Mechanisms and TherapyPARP inhibition in cancer therapy