Immunopathology of RSV: An Updated Review
Harrison C. Bergeron, Ralph A. Tripp
Abstract
RSV is a leading cause of respiratory tract disease in infants and the elderly. RSV has limited therapeutic interventions and no FDA-approved vaccine. Gaps in our understanding of virus-host interactions and immunity contribute to the lack of biological countermeasures. This review updates the current understanding of RSV immunity and immunopathology with a focus on interferon responses, animal modeling, and correlates of protection.
Topics & Concepts
ImmunopathologyImmunityImmunologyMedicineDiseaseRespiratory tractVirusMononegaviralesViral diseaseImmune systemParamyxoviridaeRespiratory systemPathologyInternal medicineRespiratory viral infections researchViral gastroenteritis research and epidemiologyAnimal Virus Infections Studies